Product Details of 182868-72-0On March 23, 2000, Jaen-Oltra, Jose; Salabert-Salvador, Ma. Teresa; Garcia-March, Francisco J.; Perez-Gimenez, Facundo; Tomas-Vert, Francisco published an article in Journal of Medicinal Chemistry. The article was 《Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods》. The article mentions the following:
A new topol. method that makes it possible to predict the properties of mols. on the basis of their chem. structures is applied in the present study to quinolone antimicrobial agents. This method uses neural networks in which training algorithms are used as well as different concepts and methods of artificial intelligence with a suitable set of topol. descriptors. This makes it possible to determine the minimal inhibitory concentration (MIC) of quinolones. Anal. of the results shows that the exptl. and calculated values are highly similar. It is possible to obtain a QSAR interpretation of the information contained in the network after the training has been carried out.1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Product Details of 182868-72-0) was used in this study.
1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 182868-72-0
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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics