Hubert, Terrance D.; Eyman, Darrell P.; Wiemer, David F. published an article in Journal of Organic Chemistry. The title of the article was 《A convenient synthesis of bis(N-methylpiperazinyl)aluminum hydride: a reagent for the reduction of carboxylic acids to aldehydes》.Electric Literature of C5H14Cl2N2 The author mentioned the following in the article:
The reaction of LiAlH4 with N-methylpiperazine (HL) and N-methylpiperazine dihydrochloride (2:3:1) is a convenient method for the preparation of AlL2H. AlL2H reduces aliphatic, aromatic, and unsaturated carboxylic acids directly to the analogous aldehydes. The facile preparation of the reagent, together with the high yields and the ease of work-up in the reductions, make AlL2H an attractive reagent for this transformation. The results came from multiple reactions, including the reaction of 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Electric Literature of C5H14Cl2N2)
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Electric Literature of C5H14Cl2N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics