The author of 《The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter》 were Latacz, Gniewomir; Kechagioglou, Petros; Papi, Rigini; Lazewska, Dorota; Wiecek, Malgorzata; Kaminska, Katarzyna; Wencel, Przemyslaw; Karcz, Tadeusz; Schwed, Johannes S.; Stark, Holger; Kyriakidis, Dimitrios A.; Kiec-Kononowicz, Katarzyna. And the article was published in Chemical Biology & Drug Design in 2016. Quality Control of 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:
The involvement of histamine and H4 receptor (H4R) in cancer has been investigated recently using the H4R agonists and antagonists. The scope of the research project was synthesis and exploration of the consequences of a group of compounds with histamine H4 receptor (H4R) affinity on the promoter of PTEN gene encoding the antitumor PTEN protein. The series of novel compounds based either on H4R antagonists JNJ7777120 structure or 1,3,5-triazine scaffold were synthesized, evaluated for histamine H4R affinity and used in this study. Compounds 5 and 7 belonging to the group of JNJ7777120 analogs showed the highest interaction with the promoter of PTEN gene and weak affinity against H4R with Ki value >100 μm. These compounds showed no significant effect on neuroblastoma IMR-32 cells viability indicating no correlation between PTEN gene promoter affinity and antitumor activity. Compound 6, another JNJ7777120 analog, showed the highest effect on IMR-32 viability with calculated IC50 = 23.27 μm. The 1,3,5-triazine derivatives exhibited generally low or medium interaction with PTEN gene promoter. However, the 1,3,5-triazine derivative 11 with the para-bromo substituent showed the highest affinity against H4R with Ki value of 520 nm and may be considered as a new lead structure. The experimental process involved the reaction of 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Quality Control of 1-Methylpiperazine dihydrochloride)
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Quality Control of 1-Methylpiperazine dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics