57260-70-5, tert-Butyl 4-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57260-70-5
General procedure: These compounds were prepared by means of the previously reported methods [44]. To a solution of tert-butyl piperazine-1-carboxylate (0.559g, 3.0mmol) and triethylamine (0.63mL, 3.3mmol) in CH2Cl2 (15mL) appropriate substituted benzyl chlorides or benzyl bromides 2a-g (3.6mmol) were added. After stirring the mixture at room temperature overnight, it was then diluted with H2O and the organics extracted with CH2Cl2 (2¡Á20mL), dried over MgSO4, and concentrated under reduced pressure. Purification of the crude material by flash column chromatography (SiO2, PE/AcOEt, 60/40) gave the corresponding intermediates. These intermediates (2.49mmol) were then treated with TFA (5.75mL, 76.8mmol) in toluene (15mL) and stirred for 80min at room temperature. After the removal of the solvent under reduced pressure, the residue was diluted with aqueous NaOH (1N) and the organics extracted with CH2Cl2 (2¡Á20mL), dried over MgSO4, and concentrated under reduced pressure to give the desired compounds 4a-g (72-89%).
57260-70-5 tert-Butyl 4-benzylpiperazine-1-carboxylate 584330, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Sadeghzadeh, Masoud; Sheibani, Shahab; Ghandi, Mehdi; Daha, Fariba Johari; Amanlou, Massoud; Arjmand, Mohammad; Hasani Bozcheloie, Abolfazl; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 488 – 497;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics