In 2019,Rasayan Journal of Chemistry included an article by Venkatasubramanian, H.; Sha, Sarojkumar; Hemalatha, S.; Easwaramoorthy, D.. Recommanded Product: 1-Methylpiperazine. The article was titled 《Synthesis, characterisation and antimicrobial activity of new nicotinamide-thiazole derivatives》. The information in the text is summarized as follows:
This work selected the already known mild active mols. such as Nicotinamide and Thiazole I [R = cyclopropyl, cyclobutyl, Ph, etc.] to enhance the activity against the disease-causing pathogens. Using peptide coupling reagent EDCI, nine compounds I were prepared and characterized by 1H NMR, Mass spectroscopy. The characterized compounds I were evaluated in-vitro antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Candida albicans by broth dilution method and zone of inhibition measured in millimeter. All the derivatives I showed good to moderate activity. Out of nine compounds I [R = thiomorpholinyl] showed better zone of inhibition between 27 mm and 34 mm. The outcomes of the result revealed that the diamide bond acts as an important pharmacophore and exposed the good inhibition behavior. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics