Zhang, Xin; Lv, Xiao-Qin; Tang, Sheng; Mei, Lin; Li, Ying-Hong; Zhang, Jing-Pu; Jiang, Jian-Dong; Peng, Zong-Gen; Song, Dan-Qing published an article in European Journal of Medicinal Chemistry. The title of the article was 《Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism》.HPLC of Formula: 1688-95-5 The author mentioned the following in the article:
Aloperine (I), a Chinese natural product with a unique endocyclic scaffold, was first identified to be a potent hepatitis C virus (HCV) inhibitor in our laboratory Thirty-four new aloperine derivatives were designed, synthesized and evaluated for their anti-HCV activities taking I as the lead. Among them, compound II exhibited the potential potency with EC50 values in a micromolar range against both wild-type and direct-acting antiviral agents (DAAs)-resistant variants, and synergistically inhibited HCV replication with approved DAAs. Furthermore, it also owned a good oral pharmacokinetic and safety profile, suggesting a highly druglike nature. The primary mechanism showed that II might target host components, distinctly different from the DAAs currently used in clinic. Therefore, we consider aloperine derivatives to be a novel class of anti-HCV agents, and compound II has been selected as a promising antiviral candidate for further investigation. In the experimental materials used by the author, we found 4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5HPLC of Formula: 1688-95-5)
4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.HPLC of Formula: 1688-95-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics