115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
After dissolving 1-(6-chloropyrimidin-4-yl)-N-(2, 6-dichloro-3,5-dimethoxyphenyl)- 1 H-benz[d]imidazol-2- amine (20 mg, 0.044 mmol) and 4-(4-ethylpiperazin-1-yl) aniline (13.6 mg, 0.066 mmol) in a mixture of 1,4-dioxane(0.1 mE) and dimethyl sulfoxide (0.1 mE) and cooling to 0 C., trifluoroacetic acid (10.2 pL, 0.133 mmol) was slowly added dropwise. Then, after heating to 120 C., the reaction mixture was stirred for 20 hours. Afier the reaction was terminated, the reaction mixture was cooled to room temperature. Afier extracting several times using ethyl acetate, the obtained organic layer was washed with water and a saturated sodium chloride solution, dried using sodium sulfate and then concentrated. The obtained residue was purified by colunm chromatography (dichloromethane/methanol, 20:1) to obtain a target compound (16 mg, 59% yield) as a yellow solid. ?H NMR (400 MHz, CDC13) oe 9.91 (brs, 1H), 8.62 (s, 1H), 7.49 (d, J=7.6 Hz, 1H), 7.28 H (m, 2H), 7.15 (t, J=7.6 Hz, 2H), 7.02 (t, J=8.0 Hz, 1H), 7.00 (d, J=8.8 Hz, 2H), 6.51 (s, 1H), 3.93 (s, 6H), 3.26 (t, J=4.6 Hz, 4H), 2.64 (t, J=4.4 Hz, 4H), 2.36 (q, J=7.2 Hz, 2H), 1.15 (t, J=7.2 Hz, 3H). ?3C NMR (400 MHz, CDC13) oe 163.49, 158.07, 156.36, 154.72, 150.63, 149.39, 142.67,135.44,131.39,129.12,124.81,123.28,120.86,117.78, 116.76, 112.85,110.17,95.25,92.88,56.47,52.64,52.30,49.03, 11.85. MSmIz: 620 [M+1].
115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; YOON, Ho Jong; YOON, Ji Hye; HUR, Woo Young; ROH, Eun Joo; KWAK, Yeon Ui; (19 pag.)US2016/145240; (2016); A1;,
Piperazine – Wikipedia
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