《2,5-Disubstituted pyridines as potent GPR119 agonists》 was written by Wu, Yulin; Kuntz, Judith D.; Carpenter, Andrew J.; Fang, Jing; Sauls, Howard R.; Gomez, Daniel J.; Ammala, Carina; Xu, Yun; Hart, Shane; Tadepalli, Sarva. Electric Literature of C7H16N2O2S And the article was included in Bioorganic & Medicinal Chemistry Letters on April 15 ,2010. The article conveys some information:
A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR anal., compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. The experimental process involved the reaction of 1-(Isopropylsulfonyl)piperazine(cas: 534615-34-4Electric Literature of C7H16N2O2S)
1-(Isopropylsulfonyl)piperazine(cas: 534615-34-4) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.Electric Literature of C7H16N2O2S
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics