With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
694499-26-8, To a stirred solution of methyl XXX (0.150 g, 0.46 mmol) and V (0.191 g, 0.70 mmol) in methanol(5 mL) was added acetic acid in catalytic amount, reaction mass was allowed to stir at RT for 30 min thenNaCNBH4 was added to the reaction mass and allowed to stirred at RT for overnight. After completion ofreaction RM was evaporated under vacuum to obtain crude which was diluted with water and product wasextracted with ethyl acetate (30 mL X 3) and brine washing was given to organic layer and dried overanhydrous Na2SO4 and evaporated under vacuum and purified though reverse phase HPLC to obtaincompound 12 (0.06 g, 22%).LCMS: 579 [M+1]+1HNMR (400 MHz, DMSO) delta 10.0 (s, 1H), 8. 2 (s, 1H), 7.9 (t, 3H), 7.5 (m, 2H), 7.4 (m, 1H), 7.3 (m, 2H),7.2 (d, 2H), 7.1 (d, 2H), 4.2 (s, 1H), 3.5 (s, 3H), 2.5 (s, 1H), 2.4 (m, 6H), 2.3 (m, 4H), 2.2 (s, 3H).
The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
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