Analyzing the synthesis route of 161357-89-7

The synthetic route of 161357-89-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

Example 5: . 2-(lH-IndoI-4-yI)-6-(4-inethanesuIfonvI-piperazin-l-vImethvI)-4- morphoIm-4-yI-thienor2,3-d1pyrimidine; 2-Chloro-6-(4-methyl-piperazm-l-ylmethyl)-4-morpholin-4-yl-thieno[2,3- dlpyrimidine ‘ 2-Chloro-4-morpholin-4-yl-thieno[2,3-d]pyrimidine-6-carbaldehyde (400 mg) and 1-methanesulfonyl-piperazine hydrochloride (1.3eq.) were stirred together in dry 1,2-dichloroethane (20 mL). After 4h sodium triacetoxyborohydride (2.3 eq.) was added and the mixture stirred overnight. The mixture was diluted with Na2CO3 solution then extracted with ethyl acetate. Combined extracts were dried (Na2SO4), filtered and concentrated. Trituration gave product (60%)., 161357-89-7

The synthetic route of 161357-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMED LIMITED; WO2007/122410; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics