Simple exploration of 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Methanesulphonyl chloride (467mu, 5.99 mmol) was added to a stirred solution of (S)-ferf-butyl 2- methylpiperazine-1-carboxylate (1 .0 g, 4.99 mmol) in dichloromethane (20 mL) and pyridine (2 mL). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was dissolved in diethyl ether (50 mL) and washed with 1 M hydrochloric acid (25 mL) followed by water (25 mL) and brine (25 mL). The organic phase was dried and evaporated. The product was dissolved in diethyl ether (20 mL) and treated with 4M hydrogen chloride in 1 ,4-dioxane (4 mL) and allowed to stand at room temperature overnight. The solvent was evaporated. The residue was triturated with diethyl ether, was filtered off, washed with diethyl ether and dried to give (S)-3-methyl-1-(methylsulphonyl)piperazine hydrochloride (457 mg, 2.128 mmol, 42.6% yield) as a colourless solid. 1H NMR (400MHz, CDCI3) delta-ppm 3.78-3.60 (m, 2H); 3.08 (dt, J = 12 Hz and J = 4 Hz, 1 H); 2.95 (J = 12 Hz and J = 4 Hz, 1 H); 2.95-2.86 (m, 2H); 2.77 (s, 3H); 2.70 (td, J = 8 Hz and J = 4Hz, 1 H); 2.31 (dd, J = 12 Hz and J = 12 Hz, 1 H); 1.09 (d, J = 8 Hz, 3H)., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE LLC; AMANS, Dominique; BAMBOROUGH, Paul; BIT, Rino, Antonio; BROWN, John, Alexander; CAMPBELL, Matthew; LINDON, Matthew, John; SHIPLEY, Tracy, Jane; THEODOULOU, Natalie, Hope; WELLAWAY, Christopher, Roland; WESTAWAY, Susan, Marie; WO2014/78257; (2014); A1;,
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