Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Category: piperazines.
Su, Ziqi;Zhang, Qi;Zhao, Qieqiang;Liu, Wenyi;Zhao, Tao;Wang, Huiping;Li, Jiarong;Xu, Juan research published 《 Synthesis and properties of sildenafil isostere》, the research content is summarized as follows. A series of novel pyrazolo[3,4-d]pyrimidin-4-one derivatives I (R1 = H, Me, Et; R2 = Me, Ph, 4-F-Ph, 4-Cl-Ph, etc.; R3 = H, Me; R4 = H, Me, Et, hydroxyethyl; R5 = H, Me; X = N, O, C) was synthesized and evaluated for their anti-phosphodiesterase-5 (PDE-5) activity. A total of 28 compounds, containing alkyl and aryl groups at the 1-N and 3-C positions on the pyrazole ring, and also bearing different alkyl substituents on the piperazine ring I were synthesized. Four compounds I (R1 = Me; R2 = Ph; R3 = H, Me; R4 = H, Et, hydroxyethyl; R5 = H, Me; X = N) and I (R1 = Et; R2 = Ph; R3 = Me; R4 = H; R5 = Me; X = N) were found to have better inhibitory activity against PDE-5 (IC50 < 10 nM). All four of the most active compounds contain a Ph ring at the N1 position. Compounds containing a 3,5-dimethylpiperazinyl group show better activity than others. These results suggest that compound I (R1 = Et; R2 = Ph; R3 = Me; R4 = H; R5 = Me; X = N) can be used as a lead structure for developing new inhibitors of PDE-5.
Category: piperazines, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics