Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Formula: C6H14N2O.
Redzicka, Aleksandra;Czyznikowska, Zaneta;Wiatrak, Benita;Gebczak, Katarzyna;Kochel, Andrzej research published 《 Design and synthesis of N-substituted 3,4-pyrroledicarboximides as potential anti-inflammatory agents》, the research content is summarized as follows. The biol. activity of the newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides I [R = Bu, Ph, 3-chlorophenyl; R1 = hydroxy; R2 = 1-hydroxyethyl, pyrimidin-2-yl, cyclohexyl etc.; X = C, N, O] was described. The compounds I were obtained in good yields by one-pot, three-component condensation of pyrrolo[3,4-c]pyrroles with secondary amines and an excess of formaldehyde solution in C2H5OH. The structural properties of the compounds I were characterized by 1H NMR, 13C NMR FT-IR, MS, and elemental anal. Moreover, single crystal X-ray diffraction has been recorded for compound I [R = 3-chlorophenyl; R2 = cyclohexyl; X = N]. The colorimetric inhibitor screening assay was used and obtained their potencies and inhibited COX-1 and COX-2 enzymes. According to the results, all of the tested compounds I inhibited the activity of COX-1 and COX-2. Theor. modeling was also applied to describes the binding properties of compoundsI towards COX-1 and COX-2 cyclooxygenase isoform. The data were supported by QSAR study.
Formula: C6H14N2O, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics