Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. COA of Formula: C6H14N2O.
Oliveira-Pinto, Sofia;Pontes, Olivia;Lopes, Diogo;Sampaio-Marques, Belem;Costa, Marta D.;Carvalho, Luisa;Goncalves, Celine S.;Costa, Bruno M.;Maciel, Patricia;Ludovico, Paula;Baltazar, Fatima;Proenca, Fernanda;Costa, Marta research published 《 Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment》, the research content is summarized as follows. A selection of new chromeno[2,3-b]pyridines I (R1 = H, Me, OMe; R2 = H, OMe; R3 = H, Me, Br, OH, etc.; X = O, NCH3, 4-FC6H4N, etc.) was prepared from chromenylacrylonitriles II and N-substituted piperazines III, using a novel and efficient synthetic procedure. The compounds I were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds I showed higher activity towards the luminal breast cancer subtype (MCF-7), competitive with the reference compound Doxorubicin. The in vivo toxicity assay using C. elegans demonstrated a safe profile for the most active compounds I. Chromene I (R1 = R3 = H; R2 = OMe; X = NCH3) revealed a promising drug profile, inhibiting cell growth and proliferation, inducing cell cycle arrest in G2/M phase, apoptosis and microtubule destabilization. The new compounds I presented exciting bioactive features and may be used as lead compounds in cancer related drug discovery.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, COA of Formula: C6H14N2O
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics