Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Computed Properties of 103-76-4.
Liu, Xiaoqin;Zang, Xufeng;Yin, Xiaoli;Yang, Wuying;Huang, Jinxiang;Huang, Jianping;Yu, Chunxian;Ke, Chunshan;Hong, Yanping research published 《 Semi-synthesis of C28-modified triterpene acid derivatives from maslinic acid or corosolic acid as potential α-glucosidase inhibitors》, the research content is summarized as follows. Combining two bioactive moieties by a covalent bond into a novel single hybrid biol. entity in view of the principle of active splicing, twenty-two C28-modified derivatives of pentacyclic dihydroxytriterpene carboxylic acids with saturated nitrogen heterocycle segments (i.e., 1-deoxynojirimycin or piperazines) have been synthesized. The inhibitory activities of all the final target compounds I (R1 = H, R2 = Me, n = 2-6, 8, 10, 12; R1 = Me, R2 = H, n = 2-6, 8, 10, 12) and II (R1 = H, R2 = Me, Y = piperazin-1-yl, Q, Q1; R1 = Me, R2 = H, Y = piperazin-1-yl, Q, Q1) on α-glucosidase were evaluated in vitro. The results of the α-glucosidase inhibition assay indicate that some derivatives, e.g., I (R1 = H, R2 = Me, n = 3): IC50 = 1468.4μM; II (R1 = H, R2 = Me, Y = Q) (III): IC50 = 499.6μM; II (R1 = H, R2 = Me, Y = Q1): IC50 = 768.5μM; and II (R1 = Me, R2 = H, Y = Q1): IC50 = 819.2μM, show superior inhibitory activity toward α-glucosidase than that of the precursor maslinic acid (IC50 = 2540.6μM) or corosolic acid (IC50 = 1363.7μM), in which compound III (IC50 = 499.6μM) possesses stronger inhibitory activity than that of acarbose (IC50 = 606μM). In addition, the result of an enzyme kinetics study reveals that the inhibitory mechanism of the compound III is non-competitive inhibition and the inhibition constant Ki is 570μM. The binding interaction between compounds with α-glucosidase are predicted by mol. docking simulation.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Computed Properties of 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics