142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
100 g (1.2 mol) of anhydrous piperazine and 240 g (1.5 mol) of piperazine dihydrochloride were heated to 120 C, 110 g (1.2 mol) of 2-chloroethanol was added dropwise, and heating and stirring were continued after the addition.Warm up to 136-140 degrees Celsius for 1 hourTLC showed that the reaction was stopped and the heating was stopped. When the temperature dropped to 80 degrees Celsius, add 500 ml of 95% ethanol, cool in the refrigerator overnight, the piperazine dihydrochloride was recovered by filtration the next day, the filter cake was washed thoroughly with a small amount of ethanol, the filtrate was combined, and 30% sodium hydroxide solution was added. 200 g of alkalized, filtered off the insoluble inorganic salt; after removing the solvent by concentration, the residue was extracted with ethyl acetate, and dried hydrogen chloride gas was introduced.After filtration and drying, a white solid 1-(2-hydroxyethyl)piperazine hydrochloride was obtained;The solids content is already above 98%. After recrystallization from a 90% aqueous solution of ethanol, 180 g of white crystals can be obtained, the yield is 85%, and the content can reach 99.5% or more., 142-64-3
142-64-3 Piperazine Dihydrochloride 8893, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Wuxi Qianhao Bio-pharmaceutical Co., Ltd.; Peng Haiyan; (4 pag.)CN109400548; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics