With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.
5625-67-2, Step 2 benzyl 3-oxopiperazine-1-carboxylate At 0C, to a mixture solution of sodium carbonate (24.77 g, 233.73 mmol, 3.00 equivalents) and piperazine-2-one (7.80 g, 77.91 mmol, 1.00 equivalent) in ethyl acetate (70.00 mL) and water (70.00 mL) was added benzyl chloroformate (16.79 g, 93.49 mmol, 13.99 mL, 95% purity, 1.20 equivalents). The reaction mixture was stirred at 30C for 16 hours. TLC showed completiton of the reaction. The mixture was subjected to extraction using ethyl acetate (80 mL*3). The combined organic layers was washed with a saturated aqueous solution of sodium chloride (80 mL*3), dried over sodium sulfate and concentrated in vacuo to give a crude product. The crude product was beaten in (petroleum ether: ethyl acetate = 20: I, 80 mL). The resulting mixture was stirred at 30C for 15 minutes and filtered. The solid was dried in vacuo to give the title compound (15.50 g, 66.17 mmol, 84.93% yield) as a white solid.
The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; DING, Charles Z.; CHEN, Shuhui; ZHAO, Baoping; XU, Zhaobing; LIU, Yingchun; LIN, Ruibin; WANG, Fei; LI, Jian; (101 pag.)EP3269715; (2018); A1;,
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