With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.
Step 2: To a solution of compound 2 (5.8 g, 20 mmol) in dichloro methane (DCM) (100 ml) was added N-bromosuccinimide (NBS) (3.74 g, 21 mmol). The mixture was stirred for -30 min at 0 C. After completion of the reaction, the mixture was directly purified by column chromatography with a mixture of petroleum ether and ethyl acetate (PE/EA) in a 5 : 1 ratio to afford the product (2.56 g, 35%).
197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.
Reference£º
Patent; ACETYLON PHARMACEUTICALS, INC.; SHEARSTONE, Jeffrey, R.; JARPE, Matthew, B.; (152 pag.)WO2016/57779; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics