The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Electric Literature of C8H8FN.Shi, Yunkai; Chen, Chao; Yang, Yaxi; Bing, zhou published the article 《Rh(III)-catalyzed selective C7-H functionalization of indolines with 1,3-enynes enables access to six-membered 1,7-fused indolines》 about this compound( cas:2343-22-8 ) in Tetrahedron Letters. Keywords: fused indoline preparation diastereoselective; indoline enyne cyclization rhodium catalyst. Let’s learn more about this compound (cas:2343-22-8).
Herein a Rh(III)-catalyzed C7-selective C-H activation/annulation of indolines I (R = H, OMe, F; R1 = H, Me, Br, Cl, F, OMe; R2 = H, Me; R3 = H, Me; R4 = H; R3R4 = -(CH2)5-; R5 = H, Me; R4R5 = -CH=CH-CH=CH-) with 1,3-enynes R6CCCH=C(CH3)2 (R6 = n-Bu, cyclopropyl, Ph, etc.) to efficiently access various privileged 1,7-fused indolines II bearing an all-carbon quaternary stereogenic carbon center was described. Notably, the resulting products II (R = R1 = R2 = R3 = R4 = R5 = H; R6 = cyclopropyl) can be readily transformed into 1,7-fused indoles III, further widening the C-7 derivatization of indoles and highlighting the synthetic utility of this methodol.
Although many compounds look similar to this compound(2343-22-8)Electric Literature of C8H8FN, numerous studies have shown that this compound(SMILES:FC1=CC2=C(NCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics