Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Enantio-differentiating hydrogenation of methyl acetoacetate over modified Raney nickel catalysts prepared by two-step modifications.Computed Properties of C5H10O3.
Two-step modifications of Raney nickel were examined for the enantio-differentiating hydrogenation of Me acetoacetate. The combination of pre-modification with disodium tartrate and NaBr in water and in-situ modification with tartaric acid resulted in the highest optical yield (84%) of hydrogenation product. This modification process is greener [environmentally benign] process than conventional modification carried out under weakly acidic conditions, because this process generated almost no Ni2+ ions. The pre-modification with tartrate and NaBr preferentially eliminated Al3+ from Raney nickel surface.
Although many compounds look similar to this compound(53562-86-0)Computed Properties of C5H10O3, numerous studies have shown that this compound(SMILES:C[C@H](O)CC(OC)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics