The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.COA of Formula: C5H10O3.Young, C. S.; Ward, O. P. published the article 《Studies of the reductive biotransformation of selected carbonyl compounds by whole cells and extracts of Baker’s yeast, Saccharomyces cerevisiae》 about this compound( cas:53562-86-0 ) in Biotechnology and Bioengineering. Keywords: carbonyl compound reduction bakers yeast; Saccharomyces citronellal benzoylformate acetoacetate reduction. Let’s learn more about this compound (cas:53562-86-0).
The progress of reductive biotransformations of a variety of carbonyl compounds by whole cells of baker’s yeast was monitored with time. Biotransformation rates ranged from 0.11 to 112.12 mg product formed per g dry yeast per h. While rapid biotransformations of citronellal and Et benzoylformate were observed, complete conversion of substrate to product did not occur. Reductive conversions of ethyl- and methyl-acetoacetate went to completion in 6 and 12 h resp. Et mandelate was produced stereoselectively, favoring the (R)-stereoisomer and ethyl- and methyl-3-hydroxybutyrate were produced with (S)-enantiospecificity. Yeast crude extract and resuspended pellet fractions converted citronellal to citronellol in the presence of NAD(P)H. Et benzoylformate and methyl- and ethyl-acetoacetate were preferentially reduced by yeast crude extract as compared to resuspended pellet and, in the case of the former two substrates, the reaction manifested a preference for NADPH over NADH.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics