Related Products of 599183-36-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Iodo-1H-indazol-5-amine, is researched, Molecular C7H6IN3, CAS is 599183-36-5, about Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists. Author is Liu, Kevin G.; Robichaud, Albert J.; Greenfield, Alexander A.; Lo, Jennifer R.; Grosanu, Cristina; Mattes, James F.; Cai, Yanxuan; Zhang, Guo Ming; Zhang, Jean Y.; Kowal, Dianne M.; Smith, Deborah L.; Di, Li; Kerns, Edward H.; Schechter, Lee E.; Comery, Thomas A..
As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT6 antagonists. The synthesis and detailed SAR of this class of compounds are reported.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics