Application In Synthesis of 1,10-Phenanthroline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Preparation, spectroscopic characterization and antitumor-antimicrobial studies of some Schiff base transition and inner transition mixed ligand complexes. Author is Khalil, Eman A. M.; Mohamed, Gehad G..
Mixed ligand complexes of Mn(II), Ni(II), Zn(II), La(III), Er(III) and Yb(III) metal ions were prepared from bidentate Schiff base ligand (L) as a primary ligand, derived from condensation of benzophenone and 1,8-naphthylenediamine, and 1,10-phenanthroline (Phen) as a secondary ligand. The new Schiff base ligand (N1-(diphenylmethylene)naphthalene-1,8-diamine) and its mixed ligand complexes were characterized by using elemental microanal., conductometric measurements, magnetic susceptibility and spectroscopic studies (UV-Vis, mass spectral anal., IR, 1H NMR and SEM). In addition, their thermal anal. (TG and DTG) behavior has been reported. Measurements of the molar conductivity of the complexes in DMF solvent pointed out the electrolytic nature of all complexes except Mn(II) and Zn(II) complexes were non electrolytes. According to the elemental analyses data, it was observed that the mixed ligand chelates had the general formulas [M(L)(Phen)Cl2]Cl.2H2O (M = La(III), Er(III) and Yb(III)), [M(L)(Phen)Cl2].H2O (M = Mn(II) and Zn(II)) and [Ni(L)(Phen)Cl(H2O)]Cl.H2O. Based on these findings, all mixed ligand complexes had octahedral geometry. The SEM image of the Schiff base ligand illustrated its rods like morphol. with and average particle size of 77 nm while, the image of Ni(II) complex showed non-uniform platelets structure with some scattered rods with an average particle size of 54 nm. Considerable applications were done to ensure the biol. significance of Schiff base ligand and its new mixed ligand complexes with Phen against Gram-neg. bacteria (Escherichia coli), Gram-pos. bacteria (Bacillus subtilis) and fungal (Aspergillus flavus and Candida albicans) strains and anti-cancer activities against (MCF7 breast cancer cell line). The results obtained revealed that the complexes exhibited promising biol. and anticancer activity. Moreover, mol. docking studies were applied to determine the probable binding mode among the Schiff base ligand and the active site of the crystal structure of E. coli YcbB acylated with meropenem (PDB ID: 6NTW) and breast cancer estrogen mutant L536S (PDB ID: 6SBO) receptors.
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