Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Alkoxyphenyl methanesulfonamides: synthesis, anti-inflammatory effect, and docking studies.Application of 54903-09-2.
A series of 2-alkoxyphenyl methanesulfonamide-based compounds were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. The compounds 4-7 showed comparable anti-inflammatory activity to rofecoxib and indomethacin, the standard drugs taken in both the studies. The synthesized compounds were also investigated for their gastric ulcerogenic potential and found to be non-ulcerogenic at the test doses. In silico (docking studies) were done to investigate the hypothetical binding mode of the target compounds to the cyclooxygenase isoenzyme (COX-2). A binding model has been proposed based on the docking studies to explain the observed pharmacol. activity of the test compounds Selected physicochem. parameters for the target compounds suggest good drug transport properties and potential bioavailability.
In addition to the literature in the link below, there is a lot of literature about this compound(6-Acetylbenzo[d]oxazol-2(3H)-one)Application of 54903-09-2, illustrating the importance and wide applicability of this compound(54903-09-2).
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics