With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.
76003-29-7, To a solution of tert-butyl 3- oxopiperazine-l-carboxylate (2.0g, 9.99 mmol) in DCM (20 ml) was added triethyloxonium tetrafluoroborate (2.0 lg, 10.99 mmol) and stirred at rt. The mixture was partitioned between EtOAc and aq NaHC03 (sat’d) and aqueous layer was extracted with EtOAc (3x). Combined organic layer was washed with brine, dried over MgS04, filtered, concentrated to give the title product as viscous oil. LC/MS:[M-56+ i] = 173.3
The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; CHOBANIAN, Harry; PIO, Barbara; GUO, Yan; DING, Fa-Xiang; DONG, Shuzhi; WALSH, Shawn, P.; JIANG, Jinlong; KIM, Dooseop; WO2015/95097; (2015); A2;,
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