Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Rhodium-catalyzed hydrofunctionalization: Enantioselective coupling of indolines and 1,3-dienes.Application of 2343-22-8.
We communicate a strategy for the hydrofunctionalization of 1,3-dienes via Rh-hydride catalysis. Conjugated dienes are coupled to nucleophiles to demonstrate the feasibility of novel C-C, C-O, C-S, and C-N bond forming processes. In the presence of a chiral JoSPOphos ligand, hydroamination generates chiral allylic amines with high regio- and enantioselectivity. Tuning both the pKa and steric properties of an acid-additive is critical for enantiocontrol.
If you want to learn more about this compound(5-Fluoroindoline)Application of 2343-22-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(2343-22-8).
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics