With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of compound 9 (100mg, 0.23mmol) in CH2Cl2 (10ml) was added oxalyl chloride (0.04ml, 0.50mmol) at 0°C, the reaction mixture was stirred at 0°C for 0.5h and then at room temperature for another 3h. The mixture was added to a solution of various amines (2.2 eq) and Et3N (0.1ml, 0.72mmol) and stirred for 12hat room temperature. After the reaction completed, the mixture was washed by water (3×20ml), brine (2×20ml), dried over anhydrous Na2SO4 and concentrated, the residue was purified by silica gel chromatography (CH2Cl2/MeOH 30/1v/v) to give corresponding diamides 10?26.
4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Mao, Shi-Wei; Chen, Huang; Yu, Li-Fang; Lv, Fang; Xing, Ya-Jing; Liu, Ting; Xie, Jia; Tang, Jie; Yi, Zhengfang; Yang, Fan; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 574 – 583;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics