694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
694499-26-8, General procedure: Step 3: General protocol for the preparation of 5-{3-(phenylcarbamoyl)-benzylamino}-lH- pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester 5-amino-iH-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester (1 eq) and 3-formyl- benzamide compound (1.1 eq) were stirred in a mixture of MeOH/AcOH (10/1; 0.06M) for 2h. Then NaBH3CN (1.2eq) was slowly added and the mixture was stirred under argon at RT overnight. The reaction was quenched by addition of saturated NaHC03 solution until neutrality. MeOH and acetic acid were evaporated. The crude was filtered and washed with water and Et20 before being purified on reverse phase (H20 l%TFA/MeCN 1%TFA 100/0, 0/100). MeCN was evaporated. The product was suspended in H20 and basified with saturated NaHC03 solution until pH = 8-9. The aqueous layer was extracted three times with AcOEt. The organic layer was dried over Na2S04, filtered and concentrated to give the expected product.
As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.
Reference£º
Patent; ORIBASE PHARMA; CHEVE, Gwenael; DAYDE-CAZALS, Benedicte; FAUVEL, Benedicte; BORIES, Cedric; YASRI, Abdelaziz; WO2014/102378; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics