With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.
Synthesis of 4-(4-morpholin-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert- butyl ester (2). A mixture of compound (1) (342 mg, 1.18 mmol), NaBH(OAc)3 (300 mg, 1.42 mmol) and morpholine (113 mul, 1.3 mmol) in DCM (5 ml) was stirred at ambient temperature overnight. Reaction was quenched with 5% aq. NaHCO3 (15 ml) and extracted with EtOAc (30 ml x 2). Organic layer was washed with brine (20 ml) and dried over MgSO4 (anh.). Solvent was evaporated in vacuum. Residue was dried in vacuum overnight to provide target compound (2) (408 mg, 96%) as white solid. LC-MS [M+H] 361.9 (C20H3 iN3O3+H, requires 362.50).
197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ACHAOGEN, INC.; WO2008/154642; (2008); A2;,
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