With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.
round bottom flask equipped with mechanical stirrer and thermometer, to dimethylsulfoxide (250 ml), pyrrolopyridine ester (IV X = F & R = CH3) (50 g) and piperazine dihydrochloride (III) (89 g) were added. To this reaction mixture, 1,8- diazabicyclo[5.4.0]undec-7-ene (DBU) (157 ml) was added and the reaction mixture washeated to 75-85 C and maintained for 48 hrs. The reaction mixture was then cooled to room temperature and ice cooled water (1000 ml) was added. Solid separated was filtered, washed with water and then dissolved in ethyl acetate (500 ml). To the ethyl acetate layer was added water (500 ml) and ethyl acetate (500 ml), organic layer was extracted, washed with water, dried and concentrated to obtain gummy mass. To thisgummy mass was added isopropyl alcohol (200 ml), stirred and filtered to obtain the crude title compound which was recrystallized from isopropyl alcohol to give the pure title compound (47 g)
1228780-72-0, 1228780-72-0 1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine 66713599, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; LUPIN LIMITED; RAJPUT, Lalitkumar, Dilipsing; VYAVHARE, Vasant, Chhabu; SHIVDAVKAR, Radhakrishna, Bhikaji; SUDRIK, Yuvraj, Dadasaheb; MITRA, Rangan; GOKHALE, Sangram; GOHEL, Sunilkumar, Vinubhai; SIYAN, Rajinder, Singh; BHISE, Nandu, Baban; SINGH, Girij, Pal; (54 pag.)WO2018/225043; (2018); A1;,
Piperazine – Wikipedia
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