With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
A Schlenk flask backfilled with N2 was charged with cw-2,6-dimethylpiperazine (0.11 g, 0.96 mmol), NaO-i-Bu (0.17 g, 1.8 mmol, (rac)-BINAP (8 mg, 0.01 mmol), Pd2(dba)3 (8 mg, 0.009 mmol), and degassed toluene (4 mL). The 2-bromotoluene (0.15 g, 0.88 mmol) was then added, and the mixture was heated under N2 at 110 ¡ãC for 24 h, cooled to rt, diluted with CH2CI2, filtered over Celite, and concentrated. The crude mixture was purified by chromatography on SiO2 (CH2Cl2 MeOH 95:5) to give the product as clear, yellow oil (140 mg, 78percent): NMR (500 MHz, CDCI3) delta 7.19-7.15 (m, 2 H), 7.02-6.98 (m, 2 H), 3.13-3.10 (m, 2 H), 3.01 (d, 7 = 10.5 Hz, 2 H), 2.35-2.31 (m, 5 H), 6 H)., 21655-48-1
The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; SKODA, Erin, M.; WANG, Zhou; WO2015/42297; (2015); A1;,
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