With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
1-lsopropylpiperazine (1.8 ml_, 12.7 mmol, 2 equiv) was added to a cold (5°C) solution of 2- chloro-5-nitropyridine (1 g, 6.3 mmol,) in DCM (5 ml_). The reaction mixture was allowed to warm to rt, stirred for 16 h, diluted with DCM and H2O. The aqueous layer was separated and extracted with DCM. The organic phase was washed with brine, dried (Na2SO4), filtered and concentrated to provide 1.58 g of he title compound as a yellow solid: ESI-MS: 251.2 [M+H]+; tR= 2.20 min.
4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NOVARTIS AG; WO2009/141386; (2009); A1;,
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