129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
At 0 deg.C, to pentafluorophenol in 520mL of anhydrous ether solution were added in portions 49g 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide (286mmol) and 12mL formic acid (312mmol). The batch was stirred at ambient temperature for 2 hours. Then add 32g 1-tert-butyl 3-methyl 1,3-piperazindicarboxylate (130mmol) and 18mL triethylamine (130mmol) dissolved in 520mL CH2Cl2 mixture. The batch was stirred at ambient temperature overnight. 1N HCl was hydrolyzed with an aqueous solution of the reaction mixture was extracted with CH2Cl2. The organic phases were then combined, then washed with saturated aqueous NaHCO3, and then washed with a saturated aqueous solution of NaCl until neutrality. Dried over MgSO4, filtered and concentrated to dryness, purified product (petroleum ether / AcOEt gradient: 0-30%) by silica gel chromatography. To give the title product as an oil.
129799-08-2, The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Les Laboratoires Servier; Vernalis (R&D) Limited; Le Tiran, A.; Le Diguarher, T.; Starck, J-B.; Henlin, J-M.; De Nanteuil, G.; Geneste, O.; Davidson, J.E.P.; Murray, J.B.; Chen, I-J.; (57 pag.)CN105579450; (2016); A;,
Piperazine – Wikipedia
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