With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
67455-41-8, General procedure: A solution of 1mmol amine/thiol and 1.2mmol alpha,beta-unsaturated nitriles or carbonyl compounds was added to bucky gel (0.1mmol) and the mixture was stirred at 25C for 1min. Likewise, the completion of the reaction was monitored using TLC. The product formed in the one-phase system, was further extracted with ether. In the same way as in the above preparation, the resulting organic phase extract was washed with a saturated solution of NaHCO3, water, and dried over Na2SO4. After removal of the solvent, the residue was further purified by recrystallization or silica gel chromatography. The reaction products were then analyzed using 1H and 13C NMR spectroscopy.
67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Attri, Pankaj; Bhatia, Rohit; Arora, Bharti; Kumar, Naresh; Park, Ji Hoon; Baik, Ku Youn; Lee, Geon Joon; Kim, In Tae; Koo, Je Huan; Choi, Eun Ha; Materials Research Bulletin; vol. 58; (2014); p. 6 – 9;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics