5294-61-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5294-61-1,N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
A mixture OF N- (2, 6-dimethylphenyl) -2-piperazinylacetamide (100 mg, 0.4 mmol) and 1- (2-methoxyphenyl) but-3-en-2-one (100 mg, 0.56 mmol), a compound of formula (12), in ethanol (2 mL) was heated at reflux for 16 hours. Ethanol was removed under reduced pressure and the residue was purified by preparative TLC, using 10% methanol in dichloromethane as mobile phase, to afford N (2, 6-dimethylphenyl)-2- {4- [4- (2-methoxyphenyl)-3-oxobutyl] piperazin-1- yl} acetamide, a compound of formula (13).
The synthetic route of 5294-61-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CV THERAPEUTICS, INC.; WO2004/63180; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics