20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
N-(4-Bromo-2-nitrophenyl)acetamide 5a (1.00 g, 3.86 mmol), 1-cyclopropylpiperazine 8a (483.26 mg, 3.86 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (446.71 mg, 0.772 mmol), tris(dibenzylideneacetone)dipalladium (353.48 mg, 0.386 mmol) and cesium carbonate (2.52 g, 7.72 mmol) were dissolved in 10 mL of toluene under the protection of argon, the solution was heated to 120 C and reacted for 4 hours. The reaction solution was cooled to room temperature, concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: B system) to obtain N-(4-(4-cyclopropylpiperazin-1-yl)-2-nitrophenyl) acetamide 8b (500 mg, red solid), yield: 42.7%. MS m/z (ESI): 304.9 [M+1]
20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Zhejiang Hisun Pharmaceutical Co., Ltd.; CHEN, Lei; GUAN, Dongliang; BAI, Hua; GOU, Jun; ZHAO, Weifeng; WANG, Zhongli; LING, Long; MA, Yutao; (59 pag.)EP3459952; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics