With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16154-72-6,3-Chloro-4-(4-methylpiperazin-1-yl)benzenamine,as a common compound, the synthetic route is as follows.
[00499] A mixture of 6-chloro-4-(2,4-dichlorophenylthio)-1H-indole-2-carboxylic acid (100 mg, 0.27 mmol), 3-chloro-4-(4-methylpiperazin-1-yl)benzenamine (122 mg, 0.54 mmol), HATU (156 mg, 0.41 mmol), Et3N (136 mg, 1.35 mmol) in DMF (5 mL) was stirred for 16 h at rt. The reaction was quenched with water (10 mL) and extracted with ethyl acetate (20 mL). The organic phase was washed water (10 mL x 2), and brine (10 mL), dried (Na2S04), filtered and concentrated in vacuo and the residue was purified by prep-HPLC (0.01%TFA) to afford 6-chloro-N-(3-chloro- 4-(4-methylpiperazin-1-yl)phenyl)-4-(2,4-dichlorophenylthio)-1H-indole-2-carboxamid (TFA salt) I-lll (56.0 mg, 0.08 mmol, 30%) as a white solid. ESI-MS (EI+ m/z): 581.0 [M+H]+. 1H MR (500 MHz, DMSO) delta 12.32 (d, J= 1.5 Hz, 1H), 10.41 (s, 1H), 9.86 (s, 1H), 7.96 (d, J= 2.5 Hz, 1H), 7.77 (d, J= 2.5 Hz, 1H), 7.71 (dd, J= 8.5 Hz, J= 2 Hz, 1H), 7.63 (s, 1H), 7.31-7.25 (m, 3H), 6.72 (d, J= 8.5 Hz, 1H), 3.52 (s, 2H), 3.49 (s, 2H), 3.24 (s, 2H), 3.00 (s, 2H), 2.88 (s, 3H)., 16154-72-6
The synthetic route of 16154-72-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
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