With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
To a dark transparent solution of 1-(4-aminophenyl)piperazine (300 mg, 1.693 mmol) and triethylamine (0.236 mL, 1.693 mmol) in DCM (30 mL) was added benzyl chloroformate (0.238 mL, 1.693 mmol) dropwise with stirring. The resulting solution was allowed to stir at rt for 1 h, after which HPLC showed reaction completion. Concentration and CombiFlash (10 g, DCM to 10% MeOH/DCM) afforded Cmpd AG as a solid. 1H-NMR (300 MHz, CDCl3) 7.35 (m, 5H), 4.80 (d, J=8.8 Hz, 2H), 6.66 (d, J=8.8 Hz, 2H), 5.16 (d, 2H), 3.65 (m, 4H), 3.49 (br-s, 2H), 2.99 (br-s, 4H), 67455-41-8
The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Vankayalapati, Hariprasad; Liu, Xiao-Hui; Hewitt, William Merton; Gourley, Eric Scott; Xu, Yong; Aavula, Bhasker; US2010/204221; (2010); A1;,
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