With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
To a mixture of IIc (9.54 g, 74.4 mmol) and K2CO3 (11.7 g, 85.1 mmol) in DMF (60 mL) 1-fluoro-2-nitrobenzene Ib (10.0 g, 70.9 mmol) was added at 25C. Obtained reaction mixture was stirred at 50C for 17 h and then water (200 mL) was added. The product was extracted to EtOAc (3 x 150 mL), combined organic layers were washed with water (3 x 100 mL) and brine (2 x 100 mL), dried over MgSO4, and solvent was evaporated to afford the title compound IIIc as orange oil which solidified upon standing. Orange crystals (17.4 g, 99% yield): 1H NMR (CDCl3, 500 MHz) delta 2.13 (s, 3H), 3.05 (m, 4H), 3.62 (m, 2H), 3.77 (m, 2H), 7.10-7.17 (m, 2H), 7.51 (m, 1 H), 7.80 (m, 1 H); MS (ESI) m/z: 250 [MH]+.
13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference£º
Patent; LEK Pharmaceuticals d.d.; The designation of the inventor has not yet been filed; EP2894154; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics