132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,132710-90-8
The 6- {4-[4-(3-piperazin- 1 -ylpropoxy)phenyl]piperazin- 1 -yl} -3-(trifluoromethyl)-7,8- dihydro[l,2,4]triazolo[4,3-b]pyridazine used as starting material was prepared as follows:-; Preparation of tert-butyl 4-[3-(4-{4-[3-(trifluoromethyl)[l,2,4]triazolo[4,3- b]pyridazin-6-yl]piperazin-l-yl}phenoxy)propyl]piperazine-l-carboxylate; DIAD (3.24 mL, 16.47 mmol) was added dropwise to 4-{4-[3- (trifluoromethyl)[ 1 ,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin- 1 -yl}phenol (obtained as described in Example 16, preparation of starting materials) (5 g, 13.72 mmol), tert-butyl 4- (3-hydroxypropyl)piperazine-l-carboxylate (CAS 132710-90-8, 5.03 g, 20.59 mmol) and triphenylphosphine (5.40 g, 20.59 mmol) in THF (50 mL) at 00C under nitrogen. The resulting solution was stirred at ambient temperature for 16 hours. The reaction mixture was evaporated to dryness and redissolved in DCM (100 mL), and washed sequentially with 2M NaOH (100 mL) and saturated brine (100 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, eluting with EtOAc. Pure fractions were evaporated to dryness to give tert-butyl 4-[3-(4-{4-[3-(trifluoromethyl)[l,2,4]t?azolo[4,3-b]pyridazin-6- yl]piperazin-l-yl}phenoxy)propyl]piperazine-l-carboxylate (3.66 g, 45%). IH NMR (399.9 MHz, CDC13) delta 1.46 (9H, s), 1.95 (2H, m), 2.40 (4H, m), 2.52 (2H, t), 3.21 (4H, m), 3.43 (4H, m), 3.78 (4H, m), 3.99 (2H, t), 6.87 (2H, d), 6.93 (2H, d), 7.11 (IH, d), 7.96 (IH, d); m/z = 591 [M+H]+.
As the paragraph descriping shows that 132710-90-8 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BRADBURY, Robert, Hugh; CARR, Gregory, Richard; RABOW, Alfred, Arthur; RAO KORUPOJU, Srinivasa; TUMMA, Harikrishna; WO2010/92371; (2010); A1;,
Piperazine – Wikipedia
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