With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
The 20 mmol 4, 6 – dichloro -2 – methyl pyrimidine, 35 mmol K3 PO4 Dissolved in 16 mmol 1 – butyl -3 – methyl imidazole glycine salt and stirring, adding 21 mmol N – hydroxyethyl piperazine, for 80 C reaction under 1.5 h after, cooling to room temperature, add-on enters 21 mmol2 – amino – N – (2 – chloro -6 – methyl phenyl) -5 – thiazole carboxamide, for 80 C continues reaction under 2 h, after the reaction, cooling to room temperature, the mixture extracted with ethyl ether 3 times (3 ¡Á 50 ml), the combined extraction liquid and concentrated, get the crude product (ionic liquid to the methylene chloride extraction, vacuum drying in order to remove the small amount of solvent, the residual viscous ionic liquid ethyl ether after being sufficiently washed directly used for the next reaction, without further purification). The crude product by adding 80% ethanol aqueous solution 100 ml, under stirring, by adding 2 g of activated carbon, reflux 30 min, is still hot filtration, filtrate refrigeration crystallization overnight, filtered, the filter cake of ice 80% ethanol aqueous solution washing, drying, to obtain white solid 9.01 g, yield 92.27%, purity of 99.94%., 103-76-4
As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.
Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Zhang Hui; Ren Qingwei; (13 pag.)CN109503568; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics