655225-01-7,655225-01-7, tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2-(5-chloro-2,4-dimethoxyphenyl)-7-(piperazin-1-yl)imidazo[1,2-a]pyridme 12 (200 mg, 0.50 mmol), tert-butyl 4-(2-bromoethyl)piperazine-1-carboxylate (160 mg, 0.53 mmol), and potassium carbonate ( 140 mg, 1.00 mmol) in acetonitriie (4 mL) was heated to reflux for 3 h. The reaction mixture was filtered and the filtrate was distilled under reduced pressure. The residue was purified by combi-flash chromatography (silica gel, 9: 1 DCM/MeOH) to afford tert-butyl 4-(2-(4-(2-(5-chloro-2,4- dimethoxyphenyl)imidazo[1 2-a]-pyridin-7-yl)piperazin-1-yl)ethyl)piperazine-1-carboxylate 13k (130 mg, 42percent) as a pale yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.38 (s, 1H), 7.88 (d, J= 7.6 Hz, 1H), 7.86 (s, 1H). 6.80 (d, J= 7.5 Hz, 1H), 6.57 (s, 1H), 6.55 (dd, J=2.3, 7.6 Hz, 1H), 3.99 (s, 3H), 3.95 (s, 3H), 3.44 (t, J= 5.1 Hz, 4H), 3.24 (t, J= 5.1 Hz, 4H), 2.66 (t, J= 5.0 Hz, 4H), 2.61-2.54 (m, 4H), 2.44 (t, J= 5.0 Hz, 4H), 1.46 (s, 9H); HPLC ( Method 1) 99.0percent (AUC), tR = 9.55 min. ; ESI MS m/z 585 [M + H]+.
As the paragraph descriping shows that 655225-01-7 is playing an increasingly important role.
Reference：
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Piperazine – Wikipedia
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