31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of tetrahydro-pyran-4-carboxylic acid (0.477 g, 2.27 mmol, 1.0 eq. ) EDCA (0.480 g, 2.50 mmol, 1.1 eq. ) and HOBt (0. 340 g, 2. 50 mmol, 1.1 eq. ) in THF/DMF (8 mL/2 mL) is kept under magnetic stirring at room temperature for about I hour. PIPERAZINE-L-CARBOXYLIC acid benzyl ester (0.438 mL, 2.27 mmol, 1. 0 eq. ) is then added and the resulting reaction mixture is left to react for 14 hours. AcOEt (10 mL) and a 10percent solution OF NAHCO3 (10 mL) are added and the phases are separated. The organic phase is then washed with water (2×10 mL) and brine (10 mL), dried on N2aSO4, filtered and the solvent removed by evaporation under reduced pressure. 4-(Tetrahydr-pyran-4-carbonyl)- piperazine-1-carboxylic acid benzyl ester (32) is obtained as an ivory coloured solid (0. 613 g, I. 85 mmol, yield = 81percent) which does not require further purification. HPLC (method A): Rt=7.71 min., 31166-44-6
The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MENARINI RICERCHE S.P.A.; WO2004/94412; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics