With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.
General procedure: To a stirring solution of compound 4a (1.2g, 4.77mmol) in 70% ethanol (20mL) were added ammonium chloride (1.28g, 23.85mmol) and reduced iron powder (0.8g, 14.31mmol). The reaction was refluxed for 5h. Upon completion, the mixture was filtered while hot and rinsed with ethyl acetate. The solvent was removed in vacuo, and the residue was purified by silica gel column chromatography (PE : EA=1 : 2) to afford compound 5a as an orange solid.
21091-98-5, The synthetic route of 21091-98-5 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
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