630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
630125-91-6, To a solution 4-(2-(cyclopropanecarboxamido)thiazolo[4,5-b]pyrazin-6- yl)benzoic acid (50 mg, 0.15 mmol) in DMF (1.0 mL) was added N, N- diisopropylethylamine (70 muL, 0.44 mmol), 2-(lH-7-azabenzotriazol-l-yl)-l, 1,3,3- tetramethyl uronium hexafluorophosphate methanaminium (112 mg, 0.29 mmol) and A- ((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)aniline (51 mg, 0.17 mmol). The reaction mixture was stirred at room temperature for 16 h. The crude product was diluted with DMSO (1 mL) and purified by preparative reverse-phase HPLC (acetonitrile/water gradient) to give the title compound as a TFA salt. 1H NuMR 600 MHz (DMSO-J6) delta 13.21 (s, IH), 10.65 (s, IH), 9.56 (bs, IH), 9.29 (s, IH), 8.36 (J, J= 7.2, IH), 8.24 (s, IH), 8.13 (m, 3H), 7.72 (J, J= 7.8 Hz, IH), 3.69 (s, 2H), 3.46 (m, 2H), 3.13 (m, 2H), 2.98 (m, 4H), 2.40 (m, 2H), 2.06 (m, IH), 1.19 (m, 3H), 1.02 (m, 4H), MS m/z : 610.25 (M + 1).
The synthetic route of 630125-91-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NOVARTIS AG; CHOI, Hwan, Geun; SIM, Taebo; GRAY, Nathanael; ZHOU, Wenjun; CHANG, Jae, Won; ZHANG, Jianming; WEISBERG, Ellen; WO2010/144909; (2010); A1;,
Piperazine – Wikipedia
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