59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 95: l-Methyl-4-[4-(methylsuIfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]piperazin-2- oneA mixture of 2-chloro-4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine (200 mg), l-methylpiperazin-2-one (157 mg) and sodium carbonate (146 mg) in DMA (4 mL) was heated in a microwave reactor at 16O0C for 10 minutes. The reaction mixture was loaded onto a SCX-2 column and product removed with 7N ammonia in methanol. The solution was evaporated to dryness and chromatographed on silica, eluting with 0 – 2.5percent methanol in DCM, to give the desired material (179 mg) as a white solid. Mass Spectrum; MH+ 370NMR Spectrum: 1H NMR (DMSOd6) 52.89 (3H, s), 3.13 (3H, s), 3.38 (2H, t), 3.55 – 3.56 (4H, m), 3.67 – 3.68 (4H, m), 3.93 (2H, t), 4.19 (2H, s), 4.28 (2H, s), 6.28 (IH, s)
59702-07-7, As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/80382; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics