21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 6 (Z)-5-(3-chloro-2-(4-cyclopentylpiperazin-1-yl)-5 (trifluoromethyl)benzylidene)thiazolidine-2,4-dione hydrochlorideA 40 mL vial was charged with a magnetic stir bar, 3-chloro-2-fluoro-5-(trifluoromethyl)benzaldehyde (0.134 ml, 1.10 mmol), acetonitrile (2.76 ml), 1-cyclopentylpiperazine (0.213 g, 1.38 mmol), and K2CO3 (0.229 g, 1.66 mmol). The vial was heated to 70 C. with stiffing for 2 h. The vessel was then cooled to rt and the mixture was diluted with DCM and filtered. The filtrate was conc. in vacuo to afford the substituted aldehyde which was dissolved in EtOH (2.76 ml). Thiazolidine-2,4-dione (0.155 g, 1.32 mmol) and piperidine (9.40 mg, 0.11 mmol) were then added and the mixture was heated to reflux for 4 h before being allowed to cool to rt. The mixture was then conc. in vacuo to afford the product which was dissolved in DMSO (2 mL) and purified via reverse phase HPLC to afford fractions that were conc. in vacuo, suspended in methanol (5 mL) and 1N HCl in diethyl ether (2 mL). This mixture was conc. in vacuo to afford (Z)-5-(3-chloro-2-(4-cyclopentylpiperazin-1-yl)-5-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione hydrochloride (0.215 g, 39.3%). 1H NMR (300 MHz, DMSO-D6) delta ppm 12.78 (s, 1H) 7.96 (s, 1H) 7.83 (s, 1H) 7.63 (s, 1H) 3.77-3.50 (m, 5H) 3.30-3.22 (m, 2H) 3.08-2.99 (m, 2H) 2.03-1.99 (m, 2H) 1.84-1.61 (m, 4H) 1.60-1.50 (m, 2H); m/z 461.
21043-40-3, As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.
Reference：
Patent; ASTRAZENECA AB; US2011/218182; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics