170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 184 3-(2,6-dichlorophenyl)-2-methyl-7-methylsulfanyl-2H-pyrimido[5,4-e][1,3]oxazin-4-one (100 mg, 0.290 mmol, 1.0 eq) in 24 toluene (10 mL) was added 25 m-CPBA (100 mg, 0.58 mmol, 2.0 eq) and allowed to stir at rt for 30 min. 66 Tert-butyl 4-(4-aminophenyl) piperazine-1-carboxylate (107 mg, 0.35 mmol, 1.10 eq) and 27 DIPEA (149 mg, 1.16 mmol, and 4.0 eq) were added and allowed to stir at rt for 1 h. Progress of reaction was monitored by LCMS. After completion of reaction, solvent was removed under reduced pressure. Crude residue was suspended in 20 mL of 7 water, extracted with ethyl acetate (50 mL×2). Combined organic layer was washed with water (20 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. Crude residue was purified by flash chromatography using 19 ethyl acetate: 20 hexane to obtain 185 tert-butyl 4-[4-[[3-(2,6-dichlorophenyl)-2-methyl-4-oxo-2H-pyrimido[5,4-e][1,3]oxazin-7-yl]amino]phenyl]piperazine-1-carboxylate (100 mg, 59.1%). (0326) LCMS: 585 [M+1]+
170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
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