38216-72-7, 1-tert-Butylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of l-fluoro-4-nitro-benzene (314mg, 2.23mmol) and 4-tert-butyl- piperazine (Ig, 3.34mmol) in dioxane (15mL) is added K2CO3 (1.65mg, 11.9mmol) and the reaction is stirred at 13O0C overnight. The solvent is evaporated under vacuum and the residue is partitioned between ethyl acetate and water. The organic layer is washed with brine, dried over MgSO4, filtered and concentrated to give a crude compound. Purification by silica gel column chromatography eluting with DCM followed by 99:1 DCM:NH3 (7M in MeOH) affords the title compound (348mg, 55.4%). LCMS: Rt 3.87min (99%)., 38216-72-7
The synthetic route of 38216-72-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Piperazine – Wikipedia
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