With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
To a solution of l-(2-hydroxyethyl)piperazine (51.7 g, 398 mmol) in DCM (500 mL) was added NEt3 (70.0 mL, 526 mmol) and dicarbonate (80.0 g, 367 mmol). The reaction mixture was stirred overnight at r.t. and then washed with IM aq Na2CO3 solution (2 x 300 mL). The organic phase was dried (MgSO4) and concentrated in vacuo to give tert-bvXy 4-(2-hydroxyethyl)piperazine-l-carboxylate (66.0 g, 72%) as a colourless oil.
103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.
Reference：
Patent; BIOVITRUM AB (publ); WO2009/147221; (2009); A1;,
Piperazine – Wikipedia
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